1-Thio-β-D-glucose sodium salt dihydrate

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1-Thio-β-D-glucose Sodium Salt Dihydrate Reference Standard (CAS 10593-29-0) 1-Thio-β-D-glucose sodium salt dihydrate is a high-purity thioglucose derivative featuring a reactive thiol group at the C-1 anomeric position. Widely utilized as an analytical standard in glycosidase enzyme inhibition assays, glucose transporter dynamics, and the synthesis of sulfur-functionalized biomolecules and gold nanoparticle self-assembled monolayers (SAMs).

  • Chemical Name: Sodium (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-thiolate dihydrate

  • Molecular Weight: 254.23 g/mol (dihydrate) | CAS Registry: 10593-29-0 | Molecular Formula: C₆H₁₁NaO₅S · 2H₂O

  • Format & Fill: 1g, 5g, or 25g sterile vial (Crystalline powder in USP Type I amber glass)

  • Purity Rating: ≥99.0% HPLC verified (Batch-specific Certificate of Analysis provided)

  • Primary Application: In vitro glycosidase assays, SAM surface chemistry, glucose transport inhibition, and biochemical synthesis.

  • Compliance: Strictly For In Vitro Laboratory Research Use Only (RUO).

Buy 1-Thio-β-D-glucose Sodium Salt Dihydrate Online | High-Purity Biochemical Standard

1-Thio-β-D-glucose sodium salt dihydrate (CAS 10593-29-0) is a premium, highly purified thiosugar reagent synthesized for advanced in vitro biochemical testing and bio-functionalization research. By substituting the oxygen atom at the anomeric C-1 hydroxyl group with a sulfur-containing thiol salt moiety, this compound serves as a pivotal chemical tool for evaluating glucose-handling enzymes and functionalizing noble metal surfaces. Reaching an analytical purity threshold of ≥99.0% via High-Performance Liquid Chromatography (HPLC), it is supplied as a standard reference material for research institutes and testing laboratories across the UK and Europe.

In quantitative biochemistry workflows, aqueous reconstitution requires precise pH control and high-grade solvent media. Laboratory procedures routinely employ reconstitution reagents such as Bacteriostatic Water or 0.6% Acetic Acid Solution to prepare stock solutions. Laboratories exploring metabolic signaling pathways often run parallel comparative evaluations with control peptides like the Semaglutide Reference Standard or Tirzepatide Reference Standard. All orders are processed under our strict Terms and Conditions and delivered via our localized UK Shipping Policy.

In Vitro Research Applications of 1-Thio-β-D-glucose Sodium Salt Dihydrate

  • Glycosidase & Enzyme Kinetics Studies: Functions as a competitive substrate or inhibitor for β-glucosidases and thioglucosidases, allowing researchers to map active-site binding kinetics and catalytic mechanisms.

  • Gold Nanoparticle Surface Functionalization: The reactive thiolate group forms stable, covalent gold-sulfur (Au-S) bonds, facilitating the self-assembly of thioglucose monolayers on nanostructures for biosensor development.

  • Structural Comparison with Auxiliary Biological Reagents:

    • 1-Thio-β-D-glucose Sodium Salt Dihydrate: An anomeric sulfur-substituted glucose analog used for surface functionalization and enzyme inhibition.

    • Epithalon Reference Standard: A synthetic peptide probe used in cell culture models analyzing gene expression profiles.

    • BPC-157 Reference Standard: A stable penta-peptide reference standard evaluated in cellular cytoprotection research.

Quality Control: Batch HPLC & NMR Verification

Every lot of 1-Thio-β-D-glucose sodium salt dihydrate undergoes comprehensive multi-tier testing to confirm molecular identity, salt stoichiometry, and chemical purity prior to release.

Plaintext

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                    ANALYTICAL TESTING BENCHMARKS
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 Test Metric             Testing Methodology        Pass Benchmark
--------------------------------------------------------------------------------
 Chemical Purity         RP-HPLC Peak Area Analysis ≥ 99.0% Main Peak
 Mass Verification       LC-MS / ESI-MS             217.20 Da (free acid) (± 0.5 Da)
 Structural Confirm.     1H-NMR & 13C-NMR           Conforms to Structure
 Physical State          Visual Inspection          White to Off-White Crystalline
================================================================================

A batch-specific Certificate of Analysis (CoA) complete with HPLC and NMR spectra is provided with every shipment. For additional analytical specifications, visit our Research Peptides FAQ or contact our laboratory desk directly through Contact ABZ Bio Lab.

Technical Specification Matrix

Quality Parameter Analytical Benchmark & Standard
Product Name 1-Thio-β-D-glucose Sodium Salt Dihydrate  
Catalog / SKU Code THIOGLU
CAS Registry Number 10593-29-0
Chemical Formula C₆H₁₁NaO₅S · 2H₂O
Molecular Mass 254.23 g/mol
Purity Grade ≥99.0% (RP-HPLC Peak Area Analysis)
Physical Appearance White to off-white crystalline solid
Solubility Profile Soluble in water (up to 50 mg/mL) and aqueous buffers; sparingly soluble in ethanol
Documentation HPLC Chromatogram & NMR Spectrometry Certificate of Analysis

Handling, Reconstitution & Storage Parameters

To prevent oxidation of the thiol functional group and maintain chemical stability:

  • Unopened Storage: Store sealed vials tightly desiccated at -20°C for long-term storage (up to 24 months). Short-term bench storage at 2°C to 8°C under nitrogen or argon atmosphere is recommended during active testing.

  • Reconstitution Guidelines: Allow the vial to reach ambient temperature prior to opening to protect against moisture condensation. Dissolve in degassed sterile laboratory water or Bacteriostatic Water. Swirl gently until completely dissolved.

  • Solution Stability: Prepare fresh aqueous solutions prior to use. Concentrated aqueous stock solutions stored at -20°C under inert gas should be used within 14 days. Review our standard Refund Policy for dispatch quality parameters.

Direct Warehouse Fulfillment & Ordering

ABZ Bio Lab ensures reliable dispatch and fulfillment for academic institutions, commercial laboratories, and industrial testing facilities:

  • Centralized Dispatch Operations: Orders are packed and shipped directly from central hubs in London and Amsterdam, eliminating international customs clearance delays for European and UK facilities.

  • Thermal Shock Packaging: Vials are packed in thermally buffered outer containers to guarantee product integrity throughout transit.

Quantity

1g Vial, 5g Vial, 25g Vial

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